Project Description

This project proposes a novel treatment of glutamate excitotoxicity which affects all neurodegenerative diseases. In case of glaucoma, it causes vision loss of 64.3 million people worldwide. This work suggests application of liposomes as detoxifying agents capable of glutamate absorption via incorporated membrane EAAT2 transporters. It is supposed that absorption of excessive glutamate by liposomes should prevent receptor over-stimulation and protect the neuron cells. Liposomes suitable for such purpose were synthetized. Their characteristics were assessed by fluorescent microscopy and Raman spectroscopy with Raman imaging.